Effect of abscess milieu on bactericidal activity of LY146032 against staphylococci

Abstract

The antistaphylococcal activity of LY146032 was tested in human pus in vitro and in a murine abscess model in vivo. The drug was not degraded by pus containing Β lactamase and had equally good or better activity than nafcillin or vancomycin against Staphylococcus aureus orStaphylococcus epidermidis in vitro and in vivo. Its activity was slightly enhanced… (More)
DOI: 10.1007/BF02018206

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