Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background.

@article{Martin2008EffectOA,
  title={Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background.},
  author={Michelle E. D. Martin and Kathy Carter and Sharon R. Jean-Philippe and Mayland Chang and Shahriar Mobashery and Sophie Thiolloy and Conor C. Lynch and Lynn M Matrisian and Barbara Fingleton},
  journal={Cancer research},
  year={2008},
  volume={68 15},
  pages={6251-9}
}
Matrix metalloproteinases (MMP) are a family of enzymes with a myriad of functions. Lately, we have come to realize that broad-spectrum inhibition of these enzymes, as was tried unsuccessfully in multiple phase III trials in cancer patients, is likely unwise given the protumorigenic and antitumorigenic functions of various family members. Here, we used the multistage mammary tumor model MMTV-PyVT to investigate roles for either MMP7 or MMP9 in tumor progression. We found no effect of genetic… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 51 extracted citations

Matrix Metalloproteinase-Induced Epithelial-Mesenchymal Transition in Breast Cancer

Journal of Mammary Gland Biology and Neoplasia • 2010
View 4 Excerpts
Highly Influenced

Transcriptomic Microenvironment of Lung Adenocarcinoma.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2017

References

Publications referenced by this paper.
Showing 1-10 of 46 references

Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis.

Proceedings of the National Academy of Sciences of the United States of America • 2006
View 4 Excerpts
Highly Influenced

New functions for the matrix metalloproteinases in cancer progression

Nature Reviews Cancer • 2002
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…