Effect of a very late antigen‐4 receptor antagonist on allergen‐induced airway responses and inflammation in asthma

@article{Diamant2005EffectOA,
  title={Effect of a very late antigen‐4 receptor antagonist on allergen‐induced airway responses and inflammation in asthma},
  author={Zuzana Diamant and Julianna Kuperus and Robert A. Baan and K Nietzmann and Sylvaine Millet and Paola Assunç{\~a}o Mendes and Barry Miller and Dilip Amin and Shashank Rohatagi and Peter J. Sterk and H C Hoogsteden and Jan-Bas Prins},
  journal={Clinical \& Experimental Allergy},
  year={2005},
  volume={35}
}
Background Very late antigen‐4 (VLA4) plays a key role in the recruitment of eosinophils in allergic responses in animal studies. 
The effect of a single inhaled dose of a VLA‐4 antagonist on allergen‐induced airway responses and airway inflammation in patients with asthma
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References

SHOWING 1-10 OF 30 REFERENCES
Blockade of late-phase airway responses and airway hyperresponsiveness in allergic sheep with a small-molecule peptide inhibitor of VLA-4.
TLDR
It is demonstrated that a small-molecule VLA-4 inhibitor, when given by aerosol, has a protective effect against antigen-induced late responses and airway hyperresponsiveness in allergic sheep.
Mechanisms regulating eosinophil extravasation in asthma.
  • E. Knol, D. Roos
  • Biology, Medicine
    The European respiratory journal. Supplement
  • 1996
TLDR
Activating cytokines, such as interleukin (IL)-5, regulated upon activation in normal T-cells (RANTES) and monocyte chemotactic peptide (MCP)-3 specifically act on eosinophils, which induce a specific infiltration into tissue allergic inflammation.
Very late antigen 4 (VLA4) antagonists as anti-inflammatory agents.
A small molecule very late antigen-4 antagonist can inhibit ovalbumin-induced lung inflammation.
TLDR
After intranasal treatment with compound A, eosinophils in the lungs and their activation products were substantially decreased, documenting its effectiveness in inhibiting lung inflammation.
Allergen‐induced fluctuation in CC chemokine receptor 3 expression on bone marrow CD34+ cells from asthmatic subjects: significance for mobilization of haemopoietic progenitor cells in allergic inflammation
TLDR
It is proposed that fluctuations in CCR3 expression on human BM CD34+ cells may facilitate chemokine‐mediated progenitor cell mobilization to the peripheral circulation and the resultant development of pulmonary eosinophilia, a cardinal feature of asthma.
Effects of inhaled budesonide on allergen-induced airway responses and airway inflammation.
TLDR
The results suggest that the effects of inhaled glucocorticosteroids on allergen-induced airway responses may be mediated through their inhibition of allergenic-induced eosinophil migration and activation.
Alpha 4 integrin antagonists.
TLDR
The rationale for targeting alpha4 integrins for the treatment of autoimmune disorders is discussed and the methods used to identify lead molecules and the progress of selected antagonists toward becoming new drugs will be discussed.
...
...