Effect of a very late antigen‐4 receptor antagonist on allergen‐induced airway responses and inflammation in asthma
@article{Diamant2005EffectOA, title={Effect of a very late antigen‐4 receptor antagonist on allergen‐induced airway responses and inflammation in asthma}, author={Zuzana Diamant and Julianna Kuperus and Robert A. Baan and K Nietzmann and Sylvaine Millet and Paola Assunç{\~a}o Mendes and Barry Miller and Dilip Amin and Shashank Rohatagi and Peter J. Sterk and H C Hoogsteden and Jan-Bas Prins}, journal={Clinical \& Experimental Allergy}, year={2005}, volume={35} }
Background Very late antigen‐4 (VLA4) plays a key role in the recruitment of eosinophils in allergic responses in animal studies.
29 Citations
The effect of a single inhaled dose of a VLA‐4 antagonist on allergen‐induced airway responses and airway inflammation in patients with asthma
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It is suggested that VLA‐4 may not play a major role in allergen‐induced airway responses and inflammation in asthma.
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Despite its demonstrated pharmacologic activity against inhaled NKA, multiple doses of AVE5883 increased the allergen-induced airway responses without affecting markers of airway hyperresponsiveness and airway inflammation.
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Very late antigen-4 integrin antagonists
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The data link the up‐regulation of the eosinophil chemotactic factor CCL26 in BP to the lesional accumulation of activated eOSinophils in the skin, which broaden the understanding of BP pathogenesis and might indicate new options for therapeutic intervention.
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