Effect of a transcriptional inactive or absent vitamin D receptor on beta-cell function and glucose homeostasis in mice.

@article{Vangoitsenhoven2016EffectOA,
  title={Effect of a transcriptional inactive or absent vitamin D receptor on beta-cell function and glucose homeostasis in mice.},
  author={Roman Vangoitsenhoven and Heidi Wolden-Kirk and Katleen Lemaire and Annemieke Verstuyf and Lieve Verlinden and Yoko Yamamoto and Shigeaki Kato and Leentje van Lommel and Frans Schuit and Bart J E P Van der Schueren and Chantal Mathieu and Lut Overbergh},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2016},
  volume={164},
  pages={
          309-317
        }
}
Vitamin D deficiency is associated with beta-cell dysfunction and a higher risk of diabetes, but mice and humans with an absence of the vitamin D receptor (VDR) display normal glucose tolerance. Here, we investigated the direct effects of absence of VDR or absence of ligand activation of VDR on beta-cell function. For this purpose, we generated mice, with a mutation in the AF2 domain of Vdr (VDRΔAF2), preventing ligand-driven transcriptional activation of vitamin D responsive genes. VDRΔAF2… CONTINUE READING