Effect of a specific serine protease inhibitor on the rat pancreas: systemic administration of camostate and exocrine pancreatic secretion.

@article{Gke1984EffectOA,
  title={Effect of a specific serine protease inhibitor on the rat pancreas: systemic administration of camostate and exocrine pancreatic secretion.},
  author={Burkhard J. G{\"o}ke and Fritz St{\"o}ckmann and R. -D. M{\"u}ller and Paul Georg Lankisch and Werner O. C. Creutzfeldt},
  journal={Digestion},
  year={1984},
  volume={30 3},
  pages={171-8}
}
Camostate, a synthetic serine protease inhibitor, specifically inhibits the trypsin activity in vitro. Immediately after intravenous administration of camostate (5, 2.5, 0.5, and 0.1 mg/kg body weight/h) the trypsin activity in the biliary-pancreatic juice was diminished dose-dependently in anaesthetized rats. The amylase release was not influenced… CONTINUE READING