• DOI:10.1016/0014-2999(86)90341-9
Corpus ID: 4619416

Effect of a smooth muscle relaxant from the stonefish, Synanceia trachynis, on KCl-induced responses in the guinea-pig vas deferens.

@article{Hoy1986EffectOA,
  title={Effect of a smooth muscle relaxant from the stonefish, Synanceia trachynis, on KCl-induced responses in the guinea-pig vas deferens.},
  author={A. W. Hoy and A. Cameron},
  journal={European journal of pharmacology},
  year={1986},
  volume={129 1-2},
  pages={
          105-12
        }
}

A. W. Hoy, A. Cameron

Published 1986

Biology, Medicine

European journal of pharmacology

Stonefish skin secretion contains a smooth muscle relaxant, synancein II, that selectively inhibits tonic responses of KCl-induced contractions of the guinea-pig vas deferens. Synancein II (5-50 micrograms/ml) and nifedipine (10(-8)-10(-7) M) reduced tonic responses equally. Over these concentrations, synancein II inhibited phasic responses more than did nifedipine. Rapid inhibition of phasic responses by synancein II (low concentrations) but its inability to block this response at high… CONTINUE READING

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