Effect of a smooth muscle relaxant from the stonefish, Synanceia trachynis, on KCl-induced responses in the guinea-pig vas deferens.

@article{Hoy1986EffectOA,
  title={Effect of a smooth muscle relaxant from the stonefish, Synanceia trachynis, on KCl-induced responses in the guinea-pig vas deferens.},
  author={A. W. Hoy and A. Cameron},
  journal={European journal of pharmacology},
  year={1986},
  volume={129 1-2},
  pages={
          105-12
        }
}
  • A. W. Hoy, A. Cameron
  • Published 1986
  • Biology, Medicine
  • European journal of pharmacology
  • Stonefish skin secretion contains a smooth muscle relaxant, synancein II, that selectively inhibits tonic responses of KCl-induced contractions of the guinea-pig vas deferens. Synancein II (5-50 micrograms/ml) and nifedipine (10(-8)-10(-7) M) reduced tonic responses equally. Over these concentrations, synancein II inhibited phasic responses more than did nifedipine. Rapid inhibition of phasic responses by synancein II (low concentrations) but its inability to block this response at high… CONTINUE READING
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    References

    SHOWING 1-10 OF 15 REFERENCES
    The antispasmogenic action on guinea-pig ileum of a fraction obtained from the toxic skin secretion of the stonefish, Synanceia trachynis.
    • A. Cameron, R. Lewis
    • Biology, Medicine
    • Toxicon : official journal of the International Society on Toxinology
    • 1982
    • 3
    Factors affecting high-potassium-induced contracture of guinea-pig vas deferens.
    • 7
    A crinotoxin from the skin tubercle glands of a stonefish (Synanceia trachynis).
    • 8
    Smooth muscle relaxing drugs and guinea pig ileum.
    • 18
    • PDF
    Mechanism of action of barium ion on rat aortic smooth muscle.
    • 54
    Inhibition of noradrenaline release by adenosine.
    • 139
    The sodium content of the smooth muscle of the guinea‐pig taenia coli
    • 62