Effect of a short-term in vitro exposure to the marine toxin domoic acid on viability, tumor necrosis factor-alpha, matrix metalloproteinase-9 and superoxide anion release by rat neonatal microglia

@article{Mayer2001EffectOA,
  title={Effect of a short-term in vitro exposure to the marine toxin domoic acid on viability, tumor necrosis factor-alpha, matrix metalloproteinase-9 and superoxide anion release by rat neonatal microglia},
  author={Alejandro M S Mayer and Mary L. Hall and Michael J Fay and Peter C Lamar and Celeste A Pearson and Walter C. Prozialeck and V K Lehmann and Peer B. Jacobson and Anne M. Romanic and Tolga Uz and Hari Manev},
  journal={BMC Pharmacology},
  year={2001},
  volume={1},
  pages={7 - 7}
}
BackgroundThe excitatory amino acid domoic acid, a glutamate and kainic acid analog, is the causative agent of amnesic shellfish poisoning in humans. No studies to our knowledge have investigated the potential contribution to short-term neurotoxicity of the brain microglia, a cell type that constitutes circa 10% of the total glial population in the brain. We tested the hypothesis that a short-term in vitro exposure to domoic acid, might lead to the activation of rat neonatal microglia and the… Expand
Differential Effects of Domoic Acid and E. coli Lipopolysaccharide on Tumor Necrosis Factor-α, Transforming Growth Factor-β1 and Matrix Metalloproteinase-9 Release by Rat Neonatal Microglia: Evaluation of the Direct Activation Hypothesis
TLDR
The observations do not support the hypothesis that a short term in vitro exposure to domoic acid activates rat neonatal microglia and the concomitant release of the pro-inflammatory mediators tumor necrosis factor-α and matrix metalloproteinases-9 (MMP-9), as well as the anti-inflammatory cytokine transforming growth factor β1 (TGF-β1). Expand
Domoic Acid-Induced Neurotoxicity Is Mainly Mediated by the AMPA/KA Receptor: Comparison between Immature and Mature Primary Cultures of Neurons and Glial Cells from Rat Cerebellum
TLDR
The expression of all studied neuronal markers was affected after DomA exposure in both immature and mature cultures, and the mature cultures seemed to be more sensitive to the treatment, as the effects were observed at lower concentrations and at earlier time points than for the immature cultures. Expand
Regional Susceptibility to Domoic Acid in Primary Astrocyte Cells Cultured from the Brain Stem and Hippocampus
TLDR
The findings suggest that astrocytes may present a possible target for pharmacological interventions for the prevention and treatment of amnesic shellfish poisoning and for other brain pathologies involving excitotoxicity. Expand
Neurotoxic effects of domoic acid on dopaminergic neurons in primary mesencephalic cell culture.
TLDR
The current study presents for the first time the neurotoxic effects of domoic acid on dopaminergic neurons and this effect appears to be attributed to activation of AMPA/KA receptors on dopaminaergic neurons. Expand
Neurological impacts of prolonged asymptomatic exposure to the marine neurotoxin domoic acid
TLDR
It is found that prolonged domoic acid exposure significantly affected gene transcription and impaired mitochondrial function in zebrafish brains, and altered neuronal network activity and connectivity in mouse brain slice cultures, all in the absence of overt symptoms, gross histopathology, and neuron death/injury. Expand
n-3 polyunsaturated fatty acids inhibit lipopolysaccharide-induced microglial activation and dopaminergic injury in rats.
Increasing evidence indicates that neuroinflammation plays an important role in neurotoxins-induced neurodegenerations. Microglia are a type of glial cells in the brain and play as the first and mainExpand
Histopathological and molecular changes produced by hippocampal microinjection of domoic acid.
TLDR
St stereotactic microinjection technique was used to administer varying amounts of DOM into the hippocampal CA1 region in order to examine potential histopathological changes after injection of sub-lethal concentrations to CA1 pyramidal neurons. Expand
Microglial glutathione and glutamate: regulation mechanisms
TLDR
Current knowledge regarding microglial GSH and its regulation is extended, and contributes to the understanding of microglia neurotoxicity and neuroprotection. Expand
Domoic Acid Toxicologic Pathology: A Review
TLDR
A comprehensive review of ASP, DOM induced pathology including ultrastructural changes associated to subchronic oral exposure, and discussion of key proposed mechanisms of cell/tissue injury involved in DOM induced brain pathology and considerations relevant to food safety and human health are provided. Expand
Proliferative effect of the phycotoxin domoic acid on cancer cell lines: a preliminary evaluation
ABSTRACT Domoic acid (DA) is a neurotoxin that causes amnesic shellfish poisoning. It is produced by algae and accumulates in shellfish. Consumption of these contaminated shellfishes is suspected toExpand
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References

SHOWING 1-10 OF 69 REFERENCES
Escherichia coli lipopolysaccharide potentiation and inhibition of rat neonatal microglia superoxide anion generation: correlation with prior lactic dehydrogenase, nitric oxide, tumor necrosis factor-alpha, thromboxane B2, and metalloprotease release.
TLDR
In vitro studies suggest that enhanced release of these four mediators (nitric oxide, TNF-alpha, thromboxane B2, and matrix metalloproteinase-9) during stimulation of BMphi with LPS might play a critical role in the subsequent ability of BM Phi to generate O2- in vivo. Expand
Domoic Acid Neurotoxicity in Cultured Cerebellar Granule Neurons Is Mediated Predominantly by NMDA Receptors that Are Activated as a Consequence of Excitatory Amino Acid Release
TLDR
Domoate‐induced neuronal injury is also mediated primarily through NMDA receptors, which are activated secondarily as a consequence of α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate (AMPA)/kainate receptor‐mediated stimulation of EAA efflux. Expand
The marine toxin domoic acid may affect the developing brain by activation of neonatal brain microglia and subsequent neurotoxic mediator generation.
  • A. Mayer
  • Biology, Medicine
  • Medical hypotheses
  • 2000
TLDR
The scientific literature strongly supports the hypothesis that the microglia may play a critical role in mediating DOM's neurotoxic effects, and the effect of DOM on microglian tissue has not been systematically investigated. Expand
Domoic acid-containing toxic mussels produce neurotoxicity in neuronal cultures through a synergism between excitatory amino acids
TLDR
It is suggested that the contemporary presence in the brain of concentrations of domoic acid insufficient alone to be toxic, together with excitatory amino acids, of endogenous and eventually of diet-related origin, may have been relevant in the occurrence of the neurological problems reported. Expand
Domoic acid: A dementia-inducing excitotoxic food poison with kainic acid receptor specificity
TLDR
In the chick embryo retina, Dom induced a lesion pattern having the same distinctive characteristics as a kainic acid lesion which differs from that induced by either NMDA or quisqualate, and the Dom lesion was blocked by CNQX but not by NMDA antagonists. Expand
Domoic acid is a potent neurotoxin to neonatal rats.
TLDR
It is concluded that neonatal rats are highly sensitive to the neuroexcitatory and lethal effects of domoic acid and that the increased sensitivity results from higher than expected serum levels of domeic acid. Expand
Therapeutic implications of microglia activation by lipopolysaccharide and reactive oxygen species generation in septic shock and central nervous system pathologies: a review.
TLDR
Reduction of microglia O2- generation is proposed as a possible complementary strategy to antioxidative therapy for septic shock and CNS pathologies that involve activated microGlia. Expand
Systemic Administration of Domoic Acid-Induced Spinal Cord Lesions in Neonatal Rats
TLDR
Data suggest that observed behavioral changes were due to spinal cord damage rather than seizures or brain lesions, and that cells in the dorsal portion of the spinal cord were relatively spared. Expand
Effects of the seafood toxin domoic acid on glutamate uptake by rat astrocytes.
  • I. A. Ross, W. Johnson, P. Sapienza, C. Kim
  • Biology, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2000
TLDR
It is suggested that domoic acid may induce neurotoxicity because of the failure of astrocytes to remove extracellular glutamate, which may contribute to excitotoxic injury. Expand
Tumor necrosis factor-α-induced gelatinase B causes delayed opening of the blood-brain barrier: an expanded therapeutic window
TLDR
G gelatinase B is the intermediate substance linking TNF to modulation of capillary permeability, and agents that interfere with transcription of proteolytic enzymes or block their action may reduce delayed capillary injury, extending the therapeutic window. Expand
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