Effect of a short CAG (glutamine) repeat on human androgen receptor function.

  title={Effect of a short CAG (glutamine) repeat on human androgen receptor function.},
  author={Dacheng Ding and Lihua Xu and Mani Menon and G Prem Veer Reddy and Evelyn R. Barrack},
  journal={The Prostate},
  volume={58 1},
BACKGROUND The human androgen receptor (AR) gene contains an uninterrupted CAG repeat that is polymorphic in length in the general population (range, 11-31 CAG's; median, 21). The CAG repeat encodes a glutamine repeat in the N-terminal transactivation domain of the AR protein. We previously reported that a 17-CAG AR gene was much more common in a cohort of men with prostate cancer (8.5%) than in the general European American population (1.3%). This suggested that a 17-CAG repeat may have… CONTINUE READING

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