Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.

  title={Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.},
  author={R. S. Kahn and Herman G. M. Westenberg and Willem M A Verhoeven and Christine Gispen-de Wied and W D Kamerbeek},
  journal={International clinical psychopharmacology},
  volume={2 1},
A double-blind placebo-controlled study of 5-HTP and clomipramine was carried out on 45 patients suffering from anxiety disorders (DSM-III). Clomipramine has shown to be effective in that it induced significant improvement on all rating scales as compared to placebo. 5-HTP showed a moderate reduction of the symptomatology on the 90-item symptoms checklist (SCL-90) and the State Scale of the Spielberger State-Trait Anxiety Inventory. Clomipramine and 5-HTP differed in their efficacy in that 5… 

Serotonin function in panic disorder: a double blind placebo controlled study with fluvoxamine and ritanserin

The findings of the present study do not support the hypothesis that 5-HT2 receptors are supersensitive in patients suffering from panic disorder, but allow no conclusions about the involvement of other 5- HT receptor subtypes.

Antidepressant drugs in anxiety disorders

  • K. Modigh
  • Psychology, Medicine
    Acta psychiatrica Scandinavica. Supplementum
  • 1987
Most investigators consider the effects in panic syndromes as well as in obsessive‐compulsive disorders to be unrelated to the antidepressant effect.

Serotonergic compounds in panic disorder, obsessive‐compulsive disorder and anxious depression: A concise review

  • J. D. den BoerH. G. M. Westenberg
  • Psychology
    Human psychopharmacology
  • 1995
Fluvoxamine is the best studied of the selective serotonin reuptake inhibitors (SSRIs) and recent double‐blind studies have confirmed earlier findings showing a reduced number and duration of panic attacks.

5-HT-related drugs and human experimental anxiety

  • A. Zuardi
  • Psychology, Biology
    Neuroscience & Biobehavioral Reviews
  • 1991

Serotonin function in panic disorder: effect of 1–5-hydroxytryptophan in patients and controls

The responsivity of the serotonergic system to 5-hydroxytryptophan (5-HTP) administration was investigated in patients with panic disorder and healthy controls, with no evidence obtained for a dysfunction of the serotonin system in patients.

5-HT1A Partial Agonists

  • Debra A. GlitzR. Pohl
  • Psychology, Biology
  • 2012
Drugs that act selectively on the serotonergic system are effective in a variety of psychiatric disorders including depression, panic disorder and obsessive compulsive disorder and such agents may help determine whether theh{ is any diagnostic specificity for abnormalities ih~olving 5-HT receptor subtypes.

Serotonin Function in Panic Disorder: Important, But Why?

It appears that, even if not the primary etiological factor in PD, the 5-HT function conveys important vulnerability, as well as adaptive factors, which may be critical in achieving progress in the treatment of patients suffering from PD.