Effect of a serotonin agonist (sumatriptan) on the peptidergic innervation of the rat cerebral dura mater and on the expression of c-fos in the caudal trigeminal nucleus in an experimental migraine model.

@article{KnyihrCsillik1997EffectOA,
  title={Effect of a serotonin agonist (sumatriptan) on the peptidergic innervation of the rat cerebral dura mater and on the expression of c-fos in the caudal trigeminal nucleus in an experimental migraine model.},
  author={Elizabeth Knyih{\'a}r-Csillik and J{\'a}nos Tajti and Mohtashem Samsam and Gyula S{\'a}ry and Sheri Slezak and L{\'a}szl{\'o} V{\'e}csei},
  journal={Journal of neuroscience research},
  year={1997},
  volume={48 5},
  pages={449-64}
}
The supratentorial cerebral dura of the albino rat is equipped with a rich sensory innervation including nociceptive axons and their terminals, which display intense calcitonin gene-related peptide (CGRP) immunoreactivity both in the connective tissue and around blood vessels. Stereotactic electrical stimulation of the trigeminal (Gasserian) ganglion, regarded as an experimental migraine model, induces marked increase and disintegration of club-like perivascular CGRP-immunopositive nerve… CONTINUE READING

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