Effect of a selective glutamate antagonist on L-dopa-induced dyskinesias in drug-naive parkinsonian monkeys.

@article{Tahar2004EffectOA,
  title={Effect of a selective glutamate antagonist on L-dopa-induced dyskinesias in drug-naive parkinsonian monkeys.},
  author={Abdallah Hadj Tahar and Laurent Gr{\'e}goire and Aur{\'e}lie Darr{\'e} and Nancy Daigle B{\'e}langer and Leonard T. Meltzer and Paul J. B{\'e}dard},
  journal={Neurobiology of disease},
  year={2004},
  volume={15 2},
  pages={
          171-6
        }
}
Alterations of striatal glutamate receptors are believed to be responsible, at least in part, for the pathogenesis of L-dopa-induced dyskinesias (LID). To evaluate whether co-administration of CI-1041, a novel NMDA receptor antagonist selective for the NR1A/NR2B subtype, with L-dopa might prevent the appearance of this side effect, eight de novo parkinsonian monkeys were treated chronically orally with either L-dopa alone or L-dopa plus CI-1041 (n= 4 for each group). After 4 weeks of treatment… CONTINUE READING