Effect of a selective 5-hydroxytryptamine reuptake inhibitor on brain extracellular noradrenaline: microdialysis studies using paroxetine.

@article{HajsKorcsok2000EffectOA,
  title={Effect of a selective 5-hydroxytryptamine reuptake inhibitor on brain extracellular noradrenaline: microdialysis studies using paroxetine.},
  author={Eva Haj{\'o}s-Korcsok and S. F. B. Mctavish and Trevor Sharp},
  journal={European journal of pharmacology},
  year={2000},
  volume={407 1-2},
  pages={101-7}
}
The clinical efficacy of selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitors (SSRIs) is normally attributed to their ability to increase brain 5-HT function although recent preclinical findings indicate that their selectivity for 5-HT over noradrenaline may be less evident in vivo. The present study investigated the effects of the SSRI, paroxetine, on extracellular levels of noradrenaline. Microdialysis was carried out in the hippocampus of the awake rat. In rats treated twice… CONTINUE READING
Blog posts, news articles and tweet counts and IDs sourced by
Altmetric.com