Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.

@article{Amato1998EffectOA,
  title={Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.},
  author={M B Amato and Carmen S{\'i}lvia Valente Barbas and Denise Machado Medeiros and Ricardo Borges Magaldi and Guilherme de Paula Pinto Schettino and Geraldo Lorenzi-Filho and Ronaldo Adib Kairalla and Daniel Deheinzelin and Carles Mu{\~n}oz and R. Souza de Oliveira and Teresa Yae Takagaki and Carlos Roberto Ribeiro Carvalho},
  journal={The New England journal of medicine},
  year={1998},
  volume={338 6},
  pages={347-54}
}
BACKGROUND In patients with the acute respiratory distress syndrome, massive alveolar collapse and cyclic lung reopening and overdistention during mechanical ventilation may perpetuate alveolar injury. We determined whether a ventilatory strategy designed to minimize such lung injuries could reduce not only pulmonary complications but also mortality at 28 days in patients with the acute respiratory distress syndrome. METHODS We randomly assigned 53 patients with early acute respiratory… CONTINUE READING
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