Effect of a polymorphism in the ND1 mitochondrial gene on human skeletal muscle mitochondrial function.

@article{Jackman2008EffectOA,
  title={Effect of a polymorphism in the ND1 mitochondrial gene on human skeletal muscle mitochondrial function.},
  author={Matthew R. Jackman and Eric Ravussin and Mark J. Rowe and R Pratley and Michelle R Milner and Wayne T. Willis},
  journal={Obesity},
  year={2008},
  volume={16 2},
  pages={363-8}
}
OBJECTIVE A non-silent polymorphism in the mitochondrial coding region of the ND1 gene, a subunit of reduced nicotinamide adenine dinucleotide (NADH) dehydrogenase is associated with resting metabolic rate (RMR) in 245 non-diabetic Pima Indians. The purpose of this investigation was to determine the effect of the ND1 gene polymorphism on mitochondrial function in 14 male Pima Indians. METHODS AND PROCEDURES Seven subjects with an A at site 3547 of the ND1 gene (Ile at amino acid 81), and… CONTINUE READING

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