Effect of a peroxisome proliferator-activated receptor gamma sumoylation mutant on neointimal formation after balloon injury in rats.

@article{Lim2009EffectOA,
  title={Effect of a peroxisome proliferator-activated receptor gamma sumoylation mutant on neointimal formation after balloon injury in rats.},
  author={Soo Yeon Lim and Byung Yong Ahn and Sung Soo Chung and Ho Seon Park and Bong Jun Cho and Min Kyoung Kim and Sung Hee Choi and In Kyu Lee and Soo-Youn Lee and Soo Joon Choi and Chin Ha Chung and Young Min Cho and Hong Kyu Lee and Kyong Soo Park},
  journal={Atherosclerosis},
  year={2009},
  volume={206 2},
  pages={
          411-7
        }
}
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear receptor regulating inflammation, atherosclerosis, insulin sensitivity and adipogenesis. Recently, it has been discovered that modification by the small ubiquitin-like modifier (SUMO) plays an important role in PPARgamma activity. In the present study, we investigated the effect of sumoylation on the antiatherogenic property of PPARgamma. PPARgamma-K107R sumoylation mutant, PPARgamma-wild type (WT) and control genes were… CONTINUE READING
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