Effect of a nonsedative dose of propofol on memory for aversively loaded information in rats.

@article{Pain2002EffectOA,
  title={Effect of a nonsedative dose of propofol on memory for aversively loaded information in rats.},
  author={Laure Pain and Marie-Jos{\'e}e Angst and Laurence LeGourrier and Philippe Oberling},
  journal={Anesthesiology},
  year={2002},
  volume={97 2},
  pages={447-53}
}
BACKGROUND The effects of propofol on memory for aversive information are not well determined. The authors evaluated the effects of a minimal nonsedative dose of propofol or midazolam on memory in rats, using an apparatus composed of two compartments: a large bright anxiogenic one and a small dark neutral one. METHODS Groups of rat received propofol (9 mg/kg, intraperitoneally) or midazolam (3 mg/kg). Anxiety was assessed in rats placed in the anxiogenic compartment as the time before the… CONTINUE READING

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