Effect of a new anti-inflammatory compound, CGP 28237, on arachidonate metabolism in rat gastrointestinal tissue

@article{Green2005EffectOA,
  title={Effect of a new anti-inflammatory compound, CGP 28237, on arachidonate metabolism in rat gastrointestinal tissue},
  author={J. Green and I. B{\"o}ttcher and B. Peskar},
  journal={Agents and Actions},
  year={2005},
  volume={23},
  pages={110-111}
}
  • J. Green, I. Böttcher, B. Peskar
  • Published 2005
  • Chemistry, Medicine
  • Agents and Actions
  • Potent non-steroidal anti-inflammatory drugs (NSAIDs) are cyclooxygenase inhibitors and this property is also thought to be a major factor in the gastrointestinal toxicity of these compounds. CGP 28237 (5-methlysulfonylamino-6-phenoxy1-indanone), a new NSAID [1], is equipotent with indomethacin in the rat adjuvant arthritis test (ED,0--0.5 mg/kg p.o.) but it has an outstanding gastrointestinal tolerability in this species up to the highest dose tested (400 mg/kg p.o. once a day for 10 days). It… CONTINUE READING
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