Effect of a lipoidic excipient on the absorption profile of compound UK 81252 in dogs after oral administration.

@article{Chang2004EffectOA,
  title={Effect of a lipoidic excipient on the absorption profile of compound UK 81252 in dogs after oral administration.},
  author={Rong-Kun Chang and Amir H. Shojaei},
  journal={Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques},
  year={2004},
  volume={7 1},
  pages={8-12}
}
PURPOSE Effect of caprylocaproyl macrogolglycerides (Labrasol), as a lipoidic excipient/vehicle in an oral capsule formulation, on pharmacokinetic disposition of a BCS Class 3 compound, UK-81252, was investigated in vivo in a canine model. METHODS The control and lipoidic formulations were administrated to six Beagle dogs in a crossover, single dose design with a 2-week washout period in between treatments. The plasma concentration-time profile for the lipoidic formulation was compared to… CONTINUE READING
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Double Weibull input function describes the complex absorption of sustained-release oral sodium valproate

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