Effect of a hypoglycaemic agent M&B 39890A on glucagon secretion in isolated rat islets of Langerhans

  title={Effect of a hypoglycaemic agent M\&B 39890A on glucagon secretion in isolated rat islets of Langerhans},
  author={Mohammad Tadayyon and Irene C. Green and David B. Cook and Jeremy David Pratt},
SummaryAdministration of the compound M&B 39890A lowered serum glucose levels significantly (p<0.001) in genetically obese mice, while no effect on serum insulin levels was observed. In in vitro experiments with isolated rat islets of Langerhans M&B 39890A inhibited arginine-stimulated glucagon release at all concentrations tested (0.5, 5.0 and 50 μmol/l). Insulin secretion was not inhibited by M&B 39890A (0.5 and 5.0 μmol/l), but was slightly decreased at 50 μmol/l. M&B 39890A (5 μmol/l) also… 


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