• DOI:10.1007/BF01788906
• Corpus ID: 34856787

Effect of a hypoglycaemic agent M&B 39890A on glucagon secretion in isolated rat islets of Langerhans

@article{Tadayyon2005EffectOA,
  title={Effect of a hypoglycaemic agent M\&B 39890A on glucagon secretion in isolated rat islets of Langerhans},
  author={Mohammad Tadayyon and Irene C. Green and David B. Cook and Jeremy David Pratt},
  journal={Diabetologia},
  year={2005},
  volume={30},
  pages={41-43}
}

• M. Tadayyon, I. Green, +1 author J. Pratt
• Published 2005
• Medicine, Biology
• Diabetologia

SummaryAdministration of the compound M&B 39890A lowered serum glucose levels significantly (p<0.001) in genetically obese mice, while no effect on serum insulin levels was observed. In in vitro experiments with isolated rat islets of Langerhans M&B 39890A inhibited arginine-stimulated glucagon release at all concentrations tested (0.5, 5.0 and 50 μmol/l). Insulin secretion was not inhibited by M&B 39890A (0.5 and 5.0 μmol/l), but was slightly decreased at 50 μmol/l. M&B 39890A (5 μmol/l) also inhibited glucagon secretion in vitro in the presence of 2 mmol/l, 6 mmol/l and 20 mmol/l glucose, while exerting no effect on insulin secretion. These results suggest that the hypoglycaemic action of M&B 39890A may be due to its direct and selective effect on glucagon secretion; this appears to operate by a mechanism different to that of glucose.