Effect of a heptapeptide angiotensin analog on aldosterone secretion in the rabbit.

@article{Neusy1980EffectOA,
  title={Effect of a heptapeptide angiotensin analog on aldosterone secretion in the rabbit.},
  author={A J Neusy and Marcia Pessah and J. Murray Steele and Jorge Lowenstein},
  journal={Kidney international},
  year={1980},
  volume={17 1},
  pages={66-73}
}
We examined the effects of an angiotensin III (AIII) analog, isoleucine-7 AIII (Ile7-AIII), on the steroidogenic and pressor responses to angiotensin II (AII) and AIII. AII or AIII (25 ng/kg/min) were infused alone or superimposed on an infusion of Ile7-AIII (100 ng/kg/min) in conscious male New Zealand rabbits. AII and AIII induced comparable increases in plasma aldosterone concentration, but AII exhibited significantly greater pressor effect. Ile7-AIII infusion resulted in significant… CONTINUE READING