Effect of a hepatitis B virus inhibitor, NZ-4, on capsid formation.

@article{Yang2016EffectOA,
  title={Effect of a hepatitis B virus inhibitor, NZ-4, on capsid formation.},
  author={Li Yang and Ya-juan Wang and Hai-jun Chen and Li-ping Shi and Xian-Kun Tong and Yang-ming Zhang and Gui-feng Wang and Wen-Long Wang and Chun-lan Feng and Pei-lan He and Yi-bin Xu and Meng-ji Lu and Wei Tang and Fa-jun Nan and Jian-ping Zuo},
  journal={Antiviral research},
  year={2016},
  volume={125},
  pages={
          25-33
        }
}
During the hepatitis B virus (HBV) life cycle, nucleocapsid assembly is essential for HBV replication. Both RNA reverse transcription and DNA replication occur within the HBV nucleocapsid. HBV nucleocapsid is consisted of core protein (HBcAg), whose carboxy-terminal domain (CTD) contains an Arg-rich domain (ARD). The ARD of HBcAg does contribute to the encapsidation of pregenomic RNA (pgRNA). Previously, we reported a small-molecule, NZ-4, which dramatically reduced the HBV DNA level in an in… CONTINUE READING
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