Effect of a dopamine antagonist on ventilation during sustained hypoxia in mice.

@article{Olson1987EffectOA,
  title={Effect of a dopamine antagonist on ventilation during sustained hypoxia in mice.},
  author={Leslie Olson and Nicholas A. Saunders},
  journal={Journal of applied physiology},
  year={1987},
  volume={62 3},
  pages={1222-6}
}
To test the hypothesis that dopamine accumulated in the carotid body limits hyperventilation during acclimatization to sustained hypoxia, we administered the dopamine antagonist droperidol to mice undergoing acclimatization to an inspired O2 fraction (FIo2) of 0.1. Twelve mice were exposed to hypoxia for 10 days and ventilation in 10% O2 and in 7% CO2 in air were measured daily by a plethysmographic method. Under both conditions ventilation increased during acclimatization to hypoxia… CONTINUE READING