Effect of a dienogest for an experimental three-dimensional endometrial culture model for endometriosis

@article{Prechapanich2013EffectOA,
  title={Effect of a dienogest for an experimental three-dimensional endometrial culture model for endometriosis},
  author={Japarath Prechapanich and Takeshi Kajihara and K. Fujita and Kazuko Sato and Satomi Uchino and Kayoko Tanaka and Sachiko Matsumoto and Masumi Akita and Masabumi Nagashima and Jan Joris Brosens and Osamu Ishihara},
  journal={Medical Molecular Morphology},
  year={2013},
  volume={47},
  pages={189-195}
}
The pathogenesis of endometriosis remains poorly understood at least in part because early stages of the disease process are difficult to investigate. Previous studies have proposed a three-dimensional fibrin matrix culture model to study human endometriosis. We examined the ultrastructural features of the endometriosis in this model and assessed the effect of a progestin on endometrial outgrowth and apoptosis in this culture system. Endometrial explants were placed in three-dimensional fibrin… CONTINUE READING

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