Effect of a cocktail on diazepam absorption

@article{Greenblatt1978EffectOA,
  title={Effect of a cocktail on diazepam absorption},
  author={David J Greenblatt and Richard I. Shader and Daniel R. Weinberger and Marcia Divoll Allen and Dean S. MacLaughlin},
  journal={Psychopharmacology},
  year={1978},
  volume={57},
  pages={199-203}
}
  • David J Greenblatt, Richard I. Shader, +2 authors Dean S. MacLaughlin
  • Published 1978
  • Psychology, Medicine
  • Psychopharmacology
  • Six healthy male or female volunteers ingested a single 5-mg tablet of diazepam with a typical ethanol-containing cocktail (1.5 ounces of 80-proof vodka plus 4 ounces of orange juice plus ice) or with a similar ethanol-free mixture (4 ounces of orange juice plus ice) in the fasting state on two occasions separated by at least 1 week. Diazepam concentrations in multiple plasma samples drawn from 15 min to 24 h after each dose were determined by electron-capture gas-liquid chromatography. Mean… CONTINUE READING

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