Effect of a Selective Mas Receptor Agonist in Cerebral Ischemia In Vitro and In Vivo

@inproceedings{Lee2015EffectOA,
  title={Effect of a Selective Mas Receptor Agonist in Cerebral Ischemia In Vitro and In Vivo},
  author={Seyoung Lee and Megan A. Evans and Hannah X. Chu and Hyun Ah Kim and Robert E. Widdop and Grant R. Drummond and Christopher G Sobey and Vardan T. Karamyan},
  booktitle={PloS one},
  year={2015}
}
Functional modulation of the non-AT1R arm of the renin-angiotensin system, such as via AT2R activation, is known to improve stroke outcome. However, the relevance of the Mas receptor, which along with the AT2R forms the protective arm of the renin-angiotensin system, as a target in stroke is unclear. Here we tested the efficacy of a selective MasR agonist, AVE0991, in in vitro and in vivo models of ischemic stroke. Primary cortical neurons were cultured from E15-17 mouse embryos for 7-9 d… CONTINUE READING
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