Effect of a Proton Pump Inhibitor or an H2-Receptor Antagonist on Prevention of Bleeding From Ulcer After Endoscopic Submucosal Dissection of Early Gastric Cancer: A Prospective Randomized Controlled Trial

@article{Uedo2007EffectOA,
  title={Effect of a Proton Pump Inhibitor or an H2-Receptor Antagonist on Prevention of Bleeding From Ulcer After Endoscopic Submucosal Dissection of Early Gastric Cancer: A Prospective Randomized Controlled Trial},
  author={Noriya Uedo and Yoji Takeuchi and Takuya Yamada and Ryu Ishihara and Hideharu Ogiyama and Sachiko Yamamoto and Motohiko Kato and Koichi Tatsumi and Eriko Masuda and Chie Tamai and Shunsuke Yamamoto and Koji Higashino and Hiroyasu Iishi and Masaharu Tatsuta},
  journal={The American Journal of Gastroenterology},
  year={2007},
  volume={102},
  pages={1610-1616}
}
OBJECTIVES:With conventional methods of endoscopic mucosal resection for early gastric cancer (EGC), proton pump inhibitors (PPIs) and H2-receptor antagonists (H2RAs) have a similar effect on preventing bleeding from artificial ulcers. An objective of this study is to investigate whether a stronger acid suppressant (i.e., PPI) more effectively prevents bleeding after the recent advanced technique of endoscopic submucosal dissection (ESD) for EGC.METHODS:This was a prospective randomized… CONTINUE READING

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Design and analysis of clinical trials: Concepts and methodologies, 2nd Ed

  • SC Chow, JP Liu
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