Effect of a P-glycoprotein inhibitor, Cyclosporin A, on the disposition in rodent brain and blood of the 5-HT1A receptor radioligand, [11C](R)-(-)-RWAY.

@article{Liow2007EffectOA,
  title={Effect of a P-glycoprotein inhibitor, Cyclosporin A, on the disposition in rodent brain and blood of the 5-HT1A receptor radioligand, [11C](R)-(-)-RWAY.},
  author={Jeih-San Liow and Shuiyu Lu and Julie A. McCarron and Jinsoo Hong and John L. Musachio and Victor W. Pike and Robert B. Innis and Sami S. Zoghbi},
  journal={Synapse},
  year={2007},
  volume={61 2},
  pages={
          96-105
        }
}
Limited brain uptake of radioligands with otherwise optimal properties for imaging brain receptors can be improved by blocking the effect of P-glycoprotein (P-gp), an efflux pump at the blood-brain barrier. Using small animal positron emission tomography (PET), we investigated how P-gp and its blockade with Cyclosporin A (CsA) affect rodent brain uptake of [(11)C](R)-(-)-RWAY, a radioligand for brain 5-HT(1A) receptors. Brain uptake of radioactivity was compared in control and CsA-treated rats… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 34 CITATIONS

Similar Papers

Loading similar papers…