Corpus ID: 4935660

Effect of a Nanoparticle-Based Multivalent Targeted Proapoptotic Peptide on Obesity

@inproceedings{Hossen2013EffectOA,
  title={Effect of a Nanoparticle-Based Multivalent Targeted Proapoptotic Peptide on Obesity},
  author={Md. Nazir Hossen and K. Kajimoto and H. Akita and M. Hyodo and H. Harashima},
  year={2013}
}
SUMMARY Antiangiogenesis has been the focus of a new strategy for the treatment of obesity. Compared to the use of a peptidomimetic (Adipotide), a proapoptotic peptide encapsulated in prohibitin (an adipose vascular marker)targeted nanoparticle (PTNP) caused a significant reduction in body weight in parallel with serum leptin, ectopic fat deposition in liver and muscle in diet-induced obese mice. Notably, the potential activity of PTNP was mediated via multivalent active recognition and uptake… Expand