Effect of a CCR5 inhibitor on viral loads in macaques dual-infected with R5 and X4 primate immunodeficiency viruses.

@article{Wolinsky2004EffectOA,
  title={Effect of a CCR5 inhibitor on viral loads in macaques dual-infected with R5 and X4 primate immunodeficiency viruses.},
  author={Steven M. Wolinsky and Ronald S Veazey and Kevin J. Kunstman and Per Johan Klasse and Jason Dufour and Andre J. Marozsan and Martin S. Springer and John P. Moore},
  journal={Virology},
  year={2004},
  volume={328 1},
  pages={19-29}
}
Human immunodeficiency virus type 1 (HIV-1) fusion with its target cells is initiated by sequential interactions between its envelope glycoprotein, CD4, and a co-receptor, usually CCR5 or CXCR4. Small molecules that bind to CCR5 and prevent its use by R5 HIV-1 strains are now being developed clinically as antiviral drugs. To test whether a block to CCR5 promotes the replication of viruses that enter cells via CXCR4 and are associated with accelerated disease progression, we administered a small… CONTINUE READING
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Rapid Communication 29 ficiency virus type 1 clones at different stages of infection : progression of disease is associated with a shift from monocytotropic to T - cell - tropic virus population

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