Effect of a 3-hour interval between methotrexate and 5-fluorouracil in the treatment of metastatic colorectal cancer.

@article{Matsumura2002EffectOA,
  title={Effect of a 3-hour interval between methotrexate and 5-fluorouracil in the treatment of metastatic colorectal cancer.},
  author={Yasuhiro Matsumura and Kunio Haruyama and Tetsuya Hamaguchi and Kuniaki Shirao and Kei Muro and Yasuhide Yamada and Yasuhiro Shimada and Kokichi Sugano},
  journal={Japanese journal of clinical oncology},
  year={2002},
  volume={32 1},
  pages={9-13}
}
OBJECTIVE This phase II study was designed to evaluate the efficacy and toxicity of 3-h interval sequential methotrexate (MTX) and 5-fluorouracil (5-FU) with leucovorin (LV) rescue in the treatment of patients with metastatic colorectal cancer. METHODS Forty-two patients with histologically confirmed metastatic colorectal cancer and at least one two-dimensionally measurable lesion, aged 30-74 years old, with performance status < or =2 and no or one prior chemotherapy were selected. Patients… CONTINUE READING