Effect of a 12-month exercise intervention on the apoptotic regulating proteins Bax and Bcl-2 in colon crypts: a randomized controlled trial.

@article{Campbell2007EffectOA,
  title={Effect of a 12-month exercise intervention on the apoptotic regulating proteins Bax and Bcl-2 in colon crypts: a randomized controlled trial.},
  author={Kristin L Campbell and Anne Mctiernan and Shuying Sue Li and Bess E Sorensen and Yutaka Yasui and Johanna W. Lampe and Irena B. King and Cornelia M Ulrich and Rebecca E Rudolph and Melinda L. Irwin and Christina M. Surawicz and Kamran Ayub and John D. Potter and Paul D Lampe},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2007},
  volume={16 9},
  pages={1767-74}
}
BACKGROUND Cellular proliferation and apoptosis (cell death) are highly regulated in the colon as insufficient apoptosis may lead to polyps and cancer. Physical activity decreases risk of colon cancer in observational studies, but the biological basis is not well defined. The objective of this study is to examine the effects of a 12-month aerobic exercise program on expression of proteins that promote (Bax) or inhibit (Bcl-2) apoptosis in colon crypts. METHODS Two hundred two sedentary… CONTINUE READING

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