Effect of Withania somnifera glycowithanolides on iron-induced hepatotoxicity in rats.

@article{Bhattacharya2000EffectOW,
  title={Effect of Withania somnifera glycowithanolides on iron-induced hepatotoxicity in rats.},
  author={Asokkumar Bhattacharya and Muthiah Ramanathan and Subhasish Ghosal and Salil Kumar Bhattacharya},
  journal={Phytotherapy research : PTR},
  year={2000},
  volume={14 7},
  pages={568-70}
}
Glycowithanolides, consisting of equimolar concentrations of sitoindosides VII-X and withaferin A, isolated from the roots of Withania somnifera Dunal, have been reported to have an antioxidant effect in the rat brain frontal cortex and striatum. In the present study, the effect of 10 days of oral administration of these active principles, in graded doses (10, 20 and 50 mg/kg), was noted on iron overload (FeSo(4), 30 mg/kg, i.p.) induced hepatotoxicity in rats. Apart from hepatic lipid… CONTINUE READING

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