Effect of Vitamin A against Methotrexate-Induced Damage to the Small Intestine in Rats

@article{Ync2004EffectOV,
  title={Effect of Vitamin A against Methotrexate-Induced Damage to the Small Intestine in Rats},
  author={M. Y{\"u}nc{\"u} and A. Eralp and M. Koruk and I. Sari and C. Bağcı and S. Inal{\"o}z},
  journal={Medical Principles and Practice},
  year={2004},
  volume={13},
  pages={346 - 352}
}
  • M. Yüncü, A. Eralp, +3 authors S. Inalöz
  • Published 2004
  • Medicine
  • Medical Principles and Practice
  • Objective: The aim of the present study was to examine whether or not the administration of vitamin A (VA) protects against methotrexate (MTX)-induced damage to small intestinal epithelium. Materials and Methods: Sixty-three male Wistar albino rats, 10–12 weeks old, weighing 240–280 g, were divided into three groups: (1) controls, (2) rats receiving MTX treatment alone, and (3) rats receiving MTX plus VA treatment. A single dose of MTX (20 mg/kg MTX in 20 ml vehicle) was administered to the… CONTINUE READING
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