Effect of Vildagliptin on Hepatic Steatosis

  title={Effect of Vildagliptin on Hepatic Steatosis},
  author={Mavin Macauley and Kieren Grant Hollingsworth and F. E. Smith and Peter E. Thelwall and Ahmad Al-Mrabeh and A. F. Schweizer and James E Foley and Roy Taylor},
  booktitle={The Journal of clinical endocrinology and metabolism},
CONTEXT Although dipeptidyl-peptidase-4 inhibitors exert their major action via an incretin mechanism, a favorable effect of vildagliptin on lipid metabolism remains unexplained. OBJECTIVE The objective was to examine hepatic triglyceride levels and insulin sensitivity on vildagliptin. DESIGN This was a 6-month, randomized, double-blind, placebo-controlled trial. SETTING This was an outpatient study at a university clinical research center. PATIENTS Individuals with type 2 diabetes (n… CONTINUE READING


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