Effect of Valsartan on Cerebellar Adrenomedullin System Dysregulation During Hypertension

  title={Effect of Valsartan on Cerebellar Adrenomedullin System Dysregulation During Hypertension},
  author={Leticia Figueira and A. Israel},
  journal={The Cerebellum},
Adrenomedullin (AM) and its receptors components, calcitonin-receptor-like receptor (CRLR), and receptor activity-modifying protein (RAMP1, RAMP2, and RAMP3) are expressed in cerebellum. Cerebellar AM, AM binding sites and receptor components are altered during hypertension, suggesting a role for cerebellar AM in blood pressure regulation. Thus, we assessed the effect of valsartan, on AM and its receptor components expression in the cerebellar vermis of Wistar Kyoto (WKY) and spontaneously… Expand
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