Effect of Vagus Nerve Stimulation on Serotonergic and Noradrenergic Transmission

  title={Effect of Vagus Nerve Stimulation on Serotonergic and Noradrenergic Transmission},
  author={Adrienne Dorr and Guy Debonnel},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={890 - 898}
  • A. Dorr, G. Debonnel
  • Published 1 August 2006
  • Biology, Psychology
  • Journal of Pharmacology and Experimental Therapeutics
Vagus nerve stimulation (VNS) is an antiepileptic treatment, which has recently shown promise as an antidepressant. Yet, its antidepressant mechanisms of action are unknown. Serotonergic [5-hydroxytryptamine (5-HT, serotonin)] and noradrenergic [norepinephrine (NE)] systems are involved in the pathophysiology of depression and in the mechanisms of action of antidepressants. The present study analyzes 5-HT and NE neuronal firing rates in their brainstem nuclei: the dorsal raphe nucleus (DRN) and… 

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