Effect of Ursodeoxycholic Acid Use on the Risk of Colorectal Neoplasia in Patients with Primary Sclerosing Cholangitis and Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

@article{Singh2013EffectOU,
  title={Effect of Ursodeoxycholic Acid Use on the Risk of Colorectal Neoplasia in Patients with Primary Sclerosing Cholangitis and Inflammatory Bowel Disease: A Systematic Review and Meta-analysis},
  author={S. Singh and S. Khanna and D. Pardi and E. Loftus and J. Talwalkar},
  journal={Inflammatory Bowel Diseases},
  year={2013},
  volume={19},
  pages={1631–1638}
}
  • S. Singh, S. Khanna, +2 authors J. Talwalkar
  • Published 2013
  • Medicine
  • Inflammatory Bowel Diseases
    • Background: Ursodeoxycholic acid (UDCA) may modify the risk of inflammatory bowel disease (IBD)–associated colorectal cancer. We performed a systematic review and meta-analysis of studies evaluating the effect of UDCA on the risk of IBD-associated colorectal neoplasia (CRN) (defined as colorectal cancer and/or dysplasia) in patients with primary sclerosing cholangitis with concomitant IBD (PSC-IBD). Methods: We conducted a systematic search of Medline, Embase, and Web of Science and manually… CONTINUE READING
    View on Wolters Kluwer
    ncbi.nlm.nih.gov
    55 Citations
    Highly Influential Citations
    3
    Background Citations
    9
    Methods Citations
    1
    Results Citations
    3
    55 Citations
    Citation Type

    Citation Type

    Reviewing the Risk of Colorectal Cancer in Inflammatory Bowel Disease After Liver Transplantation for Primary Sclerosing Cholangitis.
    • 2
    • PDF
    Ursodeoxycholic acid counteracts celecoxib in reduction of duodenal polyps in patients with familial adenomatous polyposis: a multicentre, randomized controlled trial
    • 14
    • Highly Influenced
    • PDF
    Preventing Colorectal Cancer in Patients with Inflammatory Bowel Diseases: Chemopreventive and Surgical Approaches
    Chemoprevention of colorectal cancer in ulcerative colitis: digging deep in current evidence
    • 11
    Impact of paediatric onset primary sclerosing cholangitis on clinical course and outcome of inflammatory bowel disease: a case-control population-based study in Finland
    • 2
    Inflammatory Bowel Disease and Primary Sclerosing Cholangitis: A Review of the Phenotype and Associated Specific Features
    • 36
    • PDF
    Inflammatory bowel disease of primary sclerosing cholangitis: a distinct entity?
    • 22
    • PDF
    Update on inflammatory bowel disease in patients with primary sclerosing cholangitis.
    • 41
    Management of Paediatric Ulcerative Colitis, Part 1: Ambulatory Care- an Evidence-Based Guideline from ECCO and ESPGHAN.
    • 15
    • PDF
    Specific Features of Patients With Inflammatory Bowel Disease and Primary Sclerosing Cholangitis
    • 3
    • PDF

    References

    SHOWING 1-10 OF 62 REFERENCES
    Ursodeoxycholic acid in patients with ulcerative colitis and primary sclerosing cholangitis for prevention of colon cancer: a meta-analysis
    • 17
    High-Dose Ursodeoxycholic Acid Is Associated With the Development of Colorectal Neoplasia in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis
    • 199
    Ursodeoxycholic acid treatment in IBD-patients with colorectal dysplasia and/or DNA-aneuploidy: a prospective, double-blind, randomized controlled pilot study.
    • 62
    Ursodeoxycholic acid as a chemopreventive agent in patients with ulcerative colitis and primary sclerosing cholangitis.
    • 500
    • PDF
    Ursodeoxycholic acid therapy and the risk of colorectal adenoma in patients with primary biliary cirrhosis: An observational study
    • 81
    Ursodiol Use Is Associated with Lower Prevalence of Colonic Neoplasia in Patients with Ulcerative Colitis and Primary Sclerosing Cholangitis
    • 422
    • Highly Influential
    Phase III trial of ursodeoxycholic acid to prevent colorectal adenoma recurrence.
    • 200
    • PDF
    Gender Modifies the Effect of Ursodeoxycholic Acid in a Randomized Controlled Trial in Colorectal Adenoma Patients
    • 30
    • PDF
    Risk of colorectal cancer in patients with ulcerative colitis: a meta-analysis of population-based cohort studies.
    • 541
    The risk for cancer or dysplasia in ulcerative colitis patients with primary sclerosing cholangitis
    • 324