Effect of Unilateral Low-Frequency Stimulation of Hippocampus on Rapid Kindling—Induced Seizure Development in Rats

@article{Toibaro2012EffectOU,
  title={Effect of Unilateral Low-Frequency Stimulation of Hippocampus on Rapid Kindling—Induced Seizure Development in Rats},
  author={Lucas Toibaro and Magdalena Pereyra and Julieta Pastorino and Ariela Smigliani and Florencia Ocariz and Germ{\'a}n Ortmann and Mar{\'i}a Milagros Galardi and Mar{\'i}a Bel{\'e}n Gori and Silvia Kochen},
  journal={Neuroscience and Medicine},
  year={2012},
  volume={3},
  pages={174-180}
}
Since the last decade deep brain stimulation has been proposed as an alternative treatment for patients who do not become seizure-free with the current pharmacological treatments and cannot undergo resective surgical procedure. However, the optimal stimulation parameters remain undetermined and active research in humans and animals is necessary. The present study was designed to investigate the effect of unilateral Low Frequency Stimulation (LFS) of hippocampus on seizure development by using… 
Hippocampal High-Frequency Stimulation Inhibites the Progression of Rapid Kindling-Induced Seizure in Rats
TLDR
The findings suggest that unilateral HFS applied on hippocampus effectively inhibited the epileptogenic process induced by hippocampal rapid kindling, and no conclusive information on which treatment is most efficient is found.
Low Frequency Electrical Stimulation Either Prior to Or after Rapid Kindling Stimulation Inhibits the Kindling-Induced Epileptogenesis
TLDR
Assessment of the antiepileptogenesis effects of LFS with the same protocol applied either just before or immediately after kindling stimulations found LFS-K showed more inhibiting effect than K-LFS, but the difference was not statistically significant.
Interaction of Sodium Valproate With Low-Frequency Electrical Stimulation During Kindlingn
TLDR
It seems that usage of sodium valproate with low-frequency electrical stimulation during kindling was more effective to suppress the epileptic activity than its administration alone and may have a critical role on the antiepileptic effects of sodium Valproate.
The inhibitory effect of different patterns of low frequency stimulation on neuronal firing following epileptiform activity in rat hippocampal slices
TLDR
The application of LFS (1 Hz) at 900 pulses and greater current intensity at the beginning of EA can exert a strong inhibitory effect on EA-induced neuronal hyperexcitability.
ERK activation is required for the antiepileptogenic effect of low frequency electrical stimulation in kindled rats
TLDR
Results showed ERK signaling pathway had important role in mediating the antiepileptogenic effect of LFS in perforant path kindling and increased the expression of activated ERK in the dentate gyrus.
Quantitative Analysis of the Antiepileptogenic Effects of Low Frequency Stimulation Applied Prior or After Kindling Stimulation in Rats
TLDR
Although behavioral assessments showed relatively the same level of antiepileptogenic effects for KLFS and LFSK, quantitative assessments showed more significant differences in the quantitative measures between the two protocols.

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It is demonstrated that bilateral LFS in ANT could significantly inhibit amygdala-kindled seizures by preventing both afterdischarge generation and propagation and provided further evidence for clinical use of LFSIn ANT.
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TLDR
The study suggests that unilateral low-frequency stimulation of the central piriform cortex may have a significant antiepileptogenic effect, and may be helpful for exploring effective and long-lasting therapies for human temporal lobe epilepsy.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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