Effect of Unilateral Low-Frequency Stimulation of Hippocampus on Rapid Kindling—Induced Seizure Development in Rats

  title={Effect of Unilateral Low-Frequency Stimulation of Hippocampus on Rapid Kindling—Induced Seizure Development in Rats},
  author={Lucas Toibaro and Magdalena Pereyra and Julieta Pastorino and Ariela Smigliani and Florencia Ocariz and Germ{\'a}n Ortmann and Mar{\'i}a Milagros Galardi and Mar{\'i}a Bel{\'e}n Gori and Silvia Kochen},
  journal={Neuroscience and Medicine},
Since the last decade deep brain stimulation has been proposed as an alternative treatment for patients who do not become seizure-free with the current pharmacological treatments and cannot undergo resective surgical procedure. However, the optimal stimulation parameters remain undetermined and active research in humans and animals is necessary. The present study was designed to investigate the effect of unilateral Low Frequency Stimulation (LFS) of hippocampus on seizure development by using… 
Hippocampal High-Frequency Stimulation Inhibites the Progression of Rapid Kindling-Induced Seizure in Rats
The findings suggest that unilateral HFS applied on hippocampus effectively inhibited the epileptogenic process induced by hippocampal rapid kindling, and no conclusive information on which treatment is most efficient is found.
Low Frequency Electrical Stimulation Either Prior to Or after Rapid Kindling Stimulation Inhibits the Kindling-Induced Epileptogenesis
Assessment of the antiepileptogenesis effects of LFS with the same protocol applied either just before or immediately after kindling stimulations found LFS-K showed more inhibiting effect than K-LFS, but the difference was not statistically significant.
Interaction of Sodium Valproate With Low-Frequency Electrical Stimulation During Kindlingn
It seems that usage of sodium valproate with low-frequency electrical stimulation during kindling was more effective to suppress the epileptic activity than its administration alone and may have a critical role on the antiepileptic effects of sodium Valproate.
The inhibitory effect of different patterns of low frequency stimulation on neuronal firing following epileptiform activity in rat hippocampal slices
The application of LFS (1 Hz) at 900 pulses and greater current intensity at the beginning of EA can exert a strong inhibitory effect on EA-induced neuronal hyperexcitability.
ERK activation is required for the antiepileptogenic effect of low frequency electrical stimulation in kindled rats
Results showed ERK signaling pathway had important role in mediating the antiepileptogenic effect of LFS in perforant path kindling and increased the expression of activated ERK in the dentate gyrus.
Quantitative Analysis of the Antiepileptogenic Effects of Low Frequency Stimulation Applied Prior or After Kindling Stimulation in Rats
Although behavioral assessments showed relatively the same level of antiepileptogenic effects for KLFS and LFSK, quantitative assessments showed more significant differences in the quantitative measures between the two protocols.


Low-frequency stimulation of bilateral anterior nucleus of thalamus inhibits amygdale-kindled seizures in rats
It is demonstrated that bilateral LFS in ANT could significantly inhibit amygdala-kindled seizures by preventing both afterdischarge generation and propagation and provided further evidence for clinical use of LFSIn ANT.
Unilateral low-frequency stimulation of central piriform cortex delays seizure development induced by amygdaloid kindling in rats
The study suggests that unilateral low-frequency stimulation of the central piriform cortex may have a significant antiepileptogenic effect, and may be helpful for exploring effective and long-lasting therapies for human temporal lobe epilepsy.
Comparison of hippocampal Deep Brain Stimulation with high (130Hz) and low frequency (5Hz) on afterdischarges in kindled rats
High frequency hippocampal DBS at 130Hz is more effective than LFS (5Hz) in affecting excitability in epileptic rats, reflected in a higher AD threshold and longer AD latency during application of stimulation.
Anticonvulsant effect of unilateral anterior thalamic high frequency electrical stimulation on amygdala-kindled seizures in rat
The data suggest that unilateral HFS of the ANT may be an effective method of inhibiting kindling seizures by suppressing the susceptibility to seizures and generating long lasting anti-epileptic effect preventing the recurrence of kindled seizures, providing an alternative to bilateral ANT DBS for refractory epilepsy.
Low-frequency stimulation of the kindling focus delays basolateral amygdala kindling in immature rats
Low-frequency stimulation of the kindling site suppressed afterdischarge duration and seizure stage throughout the course of kindling, which indicates a strong antiepileptogenic potential.
Effect of low-frequency electrical stimulation parameters on its anticonvulsant action during rapid perforant path kindling in rat
The results indicate that different parameters of LFS have important role in induction of L FS anticonvulsant effects, and it seems that the slower LFS frequency and the shorter interval between LFS and kindling stimulations, the stronger anticonVulsant effect will be observed.
Effect of different patterns of low-frequency stimulation on piriform cortex kindled seizures
It may be concluded that in fully kindled rats application of different patterns of LFS before kindling stimulation has no anticonvulsant effect, but it can exert an inhibitory effect when applied during an inter-seizure interval of 7 days.
Suppression of secondary generalization of limbic seizures by stimulation of subthalamic nucleus in rats.
Unilateral STN DBS showed significant suppression of the secondary generalization of limbic seizures, which implies that in addition to the nigral control of the epilepsy system, another antiepileptic mechanism such as antidromic stimulation of the corticosubthalamic pathway should be considered.
Low-frequency stimulation of the hippocampal CA3 subfield is anti-epileptogenic and anti-ictogenic in rat amygdaloid kindling model of epilepsy
The results suggest that LFS of the hippocampal CA(3) subfield is anti-epileptogenic and anti-ictogenic, and may be an alternative potential approach for temporal lobe epilepsy treatment.
Effect of low frequency stimulation of perforant path on kindling rate and synaptic transmission in the dentate gyrus during kindling acquisition in rats
It may be suggested that LFS of perforant path has a significant antiepileptogenic effect through inhibition of synaptic transmission in dentate gyrus through inhibited postsynaptic potentials and population spike amplitude during kindling acquisition.