Effect of UVB on hydrolysis of alpha-tocopherol acetate to alpha-tocopherol in mouse skin.

@article{KramerStickland1998EffectOU,
  title={Effect of UVB on hydrolysis of alpha-tocopherol acetate to alpha-tocopherol in mouse skin.},
  author={K A Kramer-Stickland and Daniel C. Liebler},
  journal={The Journal of investigative dermatology},
  year={1998},
  volume={111 2},
  pages={302-7}
}
We have assessed the hydrolysis of alpha-tocopherol acetate (alpha-TAc) to the active antioxidant alpha-tocopherol (alpha-TH) in mouse epidermis and in supernatant from epidermal homogenates. Topically administered alpha-TH prevents UVB photocarcinogenesis in C3H mice, whereas alpha-TAc does not. Hydrolysis in skin was monitored in mice treated topically with deuterium labeled alpha-TAc (d3-alpha-TAc). Epidermal samples were isolated from mice and analyzed for endogenous (d0-alpha-TAc) and d3… CONTINUE READING