Effect of UV light on small nuclear RNA synthesis: increased inhibition during postirradiation cell incubation.

@article{Morra1986EffectOU,
  title={Effect of UV light on small nuclear RNA synthesis: increased inhibition during postirradiation cell incubation.},
  author={D S Morra and Brian P. Eliceiri and George L. Eliceiri},
  journal={Molecular and cellular biology},
  year={1986},
  volume={6 3},
  pages={
          745-50
        }
}
It has been shown previously that the synthesis of small nuclear RNAs (snRNAs) U1, U2, U3, U4, and U5, in contrast to that of all other RNA species tested, decreases markedly within 2 h of cell incubation after exposure to UV light (254 nm), while pyrimidine dimers are being removed from DNA. We examined the possibility that the postirradiation cell incubation-dependent, UV light-induced inhibition of snRNA synthesis might reflect hypersensitivity of the snRNA transcriptional domains to single… CONTINUE READING
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