Effect of UTP sugar and base modifications on vaccinia virus early gene transcription.

@article{Mohamed2006EffectOU,
  title={Effect of UTP sugar and base modifications on vaccinia virus early gene transcription.},
  author={Mohamed Ragaa Mohamed and Sarah C Piacente and Benjamin K. Dickerman and Edward G. Niles},
  journal={Virology},
  year={2006},
  volume={349 2},
  pages={359-70}
}
Prior efforts demonstrated that RNA oligonucleotides containing the transcription termination signal UUUUUNU stimulate premature termination of vaccinia virus early gene transcription, in vitro. This observation suggests that viral transcription termination may be an attractive target for the development of anti-poxvirus agents. Since short RNA molecules are readily susceptible to nuclease digestion, their use would require stabilizing modifications. In order to evaluate the effect of both… CONTINUE READING