Effect of Tryptophan Treatment on Self-Biting and Central Nervous System Serotonin Metabolism in Rhesus Monkeys (Macaca mulatta)

@article{Weld1998EffectOT,
  title={Effect of Tryptophan Treatment on Self-Biting and Central Nervous System Serotonin Metabolism in Rhesus Monkeys (Macaca mulatta)},
  author={Katherine P. Weld and Joy A. Mench and Ruth A. Woodward and Monica S Bolesta and Stephen J. Suomi and James Dee Higley},
  journal={Neuropsychopharmacology},
  year={1998},
  volume={19},
  pages={314-321}
}
Two studies were conducted to examine the effects of oral L-tryptophan (TRP) supplementation as a treatment for self-injurious behavior (SIB) and to investigate behavior and central serotonin turnover of male rhesus monkeys. In Study One, TRP was administered to seven individually housed rhesus monkeys with a recent history of spontaneous SIB. While the monkeys were on TRP treatment (100 mg/kg twice a day), cisternal cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid… CONTINUE READING
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