Effect of Trinucleotide Repeats in the Huntington's Gene on Intelligence

@inproceedings{Lee2018EffectOT,
  title={Effect of Trinucleotide Repeats in the Huntington's Gene on Intelligence},
  author={Jessica K. Lee and Amy Lynn Conrad and Eric A. Epping and Kathy D. Mathews and Vincent Magnotta and Jeffrey D. Dawson and Peg Nopoulos},
  booktitle={EBioMedicine},
  year={2018}
}
BACKGROUND Huntington's Disease (HD) is caused by an abnormality in the HTT gene. This gene includes trinucleotide repeats ranging from 10 to 35, and when expanded beyond 39, causes HD. We previously reported that CAG repeats in the normal range had a direct and beneficial effect on brain development with higher repeats being associated with higher cognitive function. The current study now expands this line of inquiry to evaluate the effects of CAG repeat throughout the entire spectrum of… CONTINUE READING
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