Effect of Trigonella foenum-graecum L. on Metabolic Activity of CYP2D6 and CYP3A4.

@article{AlJenoobi2015EffectOT,
  title={Effect of Trigonella foenum-graecum L. on Metabolic Activity of CYP2D6 and CYP3A4.},
  author={Fahad Ibrahim Al-Jenoobi and Areej A. Al-Thukair and Mohd Aftab Alam and Fawkeya Abd Alla Abbas and Abdullah Mohammed Al-Mohizea and Khalid Mohammed Alkharfy and Saleh A Al-suwayeh},
  journal={Forschende Komplementarmedizin},
  year={2015},
  volume={22 3},
  pages={
          180-4
        }
}
BACKGROUND The present study investigated the effect of fenugreek seeds powder and its alcoholic extract on metabolic activity of drug-metabolizing enzymes CYP2D6 and CYP3A4. MATERIALS AND METHODS Dextromethorphan (DEX) was used as a probe for measuring metabolic activity, based on its CYP2D6- and CYP3A4-mediated metabolism to dextrorphan (DOR) and 3-methoxymorphinan (3-MM), respectively. For the in vitro investigations, DEX (25µM) was incubated with human liver microsomes and NADPH and… CONTINUE READING
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