Effect of Tiotropium on Cough Reflex Sensitivity in Acute Viral Cough

  title={Effect of Tiotropium on Cough Reflex Sensitivity in Acute Viral Cough},
  author={Peter V. Dicpinigaitis and Leah Spinner and Ganesha Santhyadka and Abdissa Negassa},
Study Objectives Cough is the most common complaint for which patients in the United States seek medical attention. Few, if any, effective therapies exist for the most common form of acute cough, that due to viral upper respiratory tract infection (URI). The aim of this study was to evaluate the effect of the anticholinergic agent tiotropium bromide on cough reflex sensitivity in subjects with acute viral URI. Patients Otherwise healthy adult nonsmokers with acute viral URI were randomized to… 

Tiotropium Attenuates Refractory Cough and Capsaicin Cough Reflex Sensitivity in Patients with Asthma.

Review: Effect of drugs on human cough reflex sensitivity to inhaled capsaicin

The current review summarizes the published experience with capsaicin inhalation challenge in the evaluation of drug effects on cough reflex sensitivity and suggests that subjects with pathological cough comprise the optimal group in which to evaluate the effect of potential antitussive agents on human cough Reflex sensitivity.

Effect of viral upper respiratory tract infection on cough reflex sensitivity.

The recently introduced concept of the Cough Hypersensitivity Syndrome may provide an explanation for the commonly observed clinical phenomenon of acute viral URI triggering what will develop into chronic, refractory cough in a subgroup of patients.

Pharmacologic management of cough.

  • D. Bolser
  • Medicine
    Otolaryngologic clinics of North America
  • 2010

Cough: an unmet clinical need

Chronic, refractory unexplained cough must be distinguished from cough that has not been fully evaluated and treated according to current guideline recommendations, and new safe and effective anti‐tussive agents for use when cough suppression is desired, regardless of underlying aetiology of cough.

Currently available antitussives.

Pharmacological Therapy of Acute and Chronic Cough

A recent therapeutic approach to refractory cough is reported, represented by the combination of behavioural therapy and the neuromodulator drugs.



Capsaicin cough sensitivity increases during upper respiratory infection.

Effect of bronchodilators on the cough response to inhaled citric acid in normal and asthmatic subjects.

The simplest hypothesis which explains the results relates change in cough response to altered neuroreceptor sensitivity associated with rapid changes in bronchial calibre to changes in respiratory resistance to salbutamol.

Effect of inhaled procaterol on cough receptor sensitivity to capsaicin in patients with asthma or chronic bronchitis and in normal subjects.

The attenuation of the cough sensitivity seen after inhalation of procaterol in patients with asthma and bronchitis may result from tachyphylaxis to capsaicin.

The influence of gender on cough reflex sensitivity.

Healthy women have a more sensitive cough reflex than do healthy men, and the reasons remain to be elucidated, but may involve a heightened sensitivity, in women, of the sensory receptors within the respiratory tract that mediate cough.

The effect of altering airway tone on the sensitivity of the cough reflex in normal volunteers.

If bronchodilator drugs are antitussive in non-asthmatic patients, then this is unlikely to be due to an effect on the sensitivity of the cough reflex, as both baseline respiratory resistance and resistance measured after capsaicin are low.

Short- and long-term reproducibility of capsaicin cough challenge testing.

Inhaled anti-cholinergics for prolonged non-specific cough in children.

There is currently no evidence to support the use of inhaled anti-cholinergics for symptomatic control of non-specific cough in children, and further research is needed.

Sex-related differences in cough reflex sensitivity in patients with chronic cough.

A sex difference in cough sensitivity in patients with chronic cough, as previously reported in healthy volunteers, is indicated, which may explain the female preponderance in cough clinics.

Codeine, cough and upper respiratory infection.

Evidence in the literature indicates that codeine inhibits fictive cough in animal models and also has antitussive activity against both induced and chronic cough models in man, and a hypothesis is put forward that there are two cough pathways in man.