Effect of Theophylline on the Production of Interleukin-1β, Tumor Necrosis Factor-α, and Interleukin-8 by Human Peripheral Blood Mononuclear Cells

  title={Effect of Theophylline on the Production of Interleukin-1$\beta$, Tumor Necrosis Factor-$\alpha$, and Interleukin-8 by Human Peripheral Blood Mononuclear Cells},
  author={Tomoaki Yoshimura and Eiseki Usami and Chikako Kurita and Shino Watanabe and Toshiya Nakao and Joji Kobayashi and Futoshi Yamazaki and Hiroichi Nagai},
  journal={Biological \& Pharmaceutical Bulletin},
Theophylline is a mild bronchodilator and has significant extrapulmonary effects, but it may also have some anti-inflammatory properties. We investigated the immunological effects of theophylline on peripheral blood mononuclear cells (PBMC), by examining the production of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and interleukin 8 (IL-8) when PBMC were stimulated with lipopolysaccharide (LPS) or recombinant human IL-1β (rhIL-1β). At concentrationsl50μg/ml, theophylline suppressed… 
Theophylline Inhibits NF-κB Activation in Human Peripheral Blood Mononuclear Cells
Findings are consistent with the idea that theophylline suppresses the production of proinflammatory cytokines via inhibition of NF-ĸB activation through preservation of the I ĸBα protein in monocytes/macrophages and T cells.
Expression of IL-8 gene in human monocytes and lymphocytes: differential regulation by TNF and IL-1.
The data demonstrate major differences in responsiveness of MO and LY to exogenous TNF-alpha and IL-1, and suggest relative autonomy of IL-8 gene expression in these cells that does not require accessory cytokines but can be induced directly by exogenous stimuli.
Effect of theophylline on induced sputum inflammatory indices and neutrophil chemotaxis in chronic obstructive pulmonary disease.
It is suggested that theophylline has antiinflammatory properties that may be useful in the long-term treatment of COPD.
Theophylline Alters Neutrophil Function in Preterm Infants
Theophylline concentrations in the high therapeutic range cause dose-dependent reductions in neutrophil chemiluminescence, chemotaxis, and random motility, and this effect may affect the infants’ response to infection as well as the incidence of inflammatory diseases.
Effects of aminophylline on cytokines and pulmonary function in patients undergoing valve replacement.
  • W. Luo, Xiang Ling, Ri-mao Huang
  • Medicine
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • 2004
Systemic Inflammation in the Genesis of Frailty and Sarcopenia: An Overview of the Preventative and Therapeutic Role of Exercise and the Potential for Drug Treatments
It is increasingly apparent that in older adults there is a tendency for the innate immune network to shift toward a pro-inflammatory setting, often due to the presence of chronic inflammatory diseases but also associated with age alone in some individuals.