Effect of Theophylline on the Production of Interleukin-1β, Tumor Necrosis Factor-α, and Interleukin-8 by Human Peripheral Blood Mononuclear Cells

@article{Yoshimura1995EffectOT,
  title={Effect of Theophylline on the Production of Interleukin-1$\beta$, Tumor Necrosis Factor-$\alpha$, and Interleukin-8 by Human Peripheral Blood Mononuclear Cells},
  author={Tomoaki Yoshimura and Eiseki Usami and Chikako Kurita and Shino Watanabe and Toshiya Nakao and Joji Kobayashi and Futoshi Yamazaki and Hiroichi Nagai},
  journal={Biological \& Pharmaceutical Bulletin},
  year={1995},
  volume={18},
  pages={1405-1408}
}
Theophylline is a mild bronchodilator and has significant extrapulmonary effects, but it may also have some anti-inflammatory properties. We investigated the immunological effects of theophylline on peripheral blood mononuclear cells (PBMC), by examining the production of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and interleukin 8 (IL-8) when PBMC were stimulated with lipopolysaccharide (LPS) or recombinant human IL-1β (rhIL-1β). At concentrationsl50μg/ml, theophylline suppressed… 
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