Effect of Th2 type cytokines on hCLCA1 and mucus expression in cystic fibrosis airways.

@article{Hauber2010EffectOT,
  title={Effect of Th2 type cytokines on hCLCA1 and mucus expression in cystic fibrosis airways.},
  author={Hans Peter Hauber and Francois Lavigne and Hsiao-Ling Hung and Roy C Levitt and Qutayba A Hamid},
  journal={Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society},
  year={2010},
  volume={9 4},
  pages={
          277-9
        }
}

• Hans Peter Hauber, Francois Lavigne, +2 authors Qutayba A Hamid
• Published in
  Journal of cystic fibrosis : official journal of…
  2010
• DOI:10.1016/j.jcf.2010.05.002

Correlations between expression of interleukin (IL)-9, the calcium-activated chloride channel hCLCA1 and mucus expression in cystic fibrosis (CF) airways have suggested a causal relationship. To verify this hypothesis mucosal tissue from upper airways of CF patients (N=5) was stimulated with the Th2 type cytokines IL-4, IL-9, or IL-13. Expression of hCLCA1 mRNA and protein as well as mucus and mucin (MUC5AC) gene expression was quantified using real time PCR, immunohistochemistry (hCLCA1) and… CONTINUE READING

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