Effect of Th2 type cytokines on hCLCA1 and mucus expression in cystic fibrosis airways.

@article{Hauber2010EffectOT,
  title={Effect of Th2 type cytokines on hCLCA1 and mucus expression in cystic fibrosis airways.},
  author={Hans Peter Hauber and Francois Lavigne and Hsiao-Ling Hung and Roy C Levitt and Qutayba A Hamid},
  journal={Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society},
  year={2010},
  volume={9 4},
  pages={
          277-9
        }
}
Correlations between expression of interleukin (IL)-9, the calcium-activated chloride channel hCLCA1 and mucus expression in cystic fibrosis (CF) airways have suggested a causal relationship. To verify this hypothesis mucosal tissue from upper airways of CF patients (N=5) was stimulated with the Th2 type cytokines IL-4, IL-9, or IL-13. Expression of hCLCA1 mRNA and protein as well as mucus and mucin (MUC5AC) gene expression was quantified using real time PCR, immunohistochemistry (hCLCA1) and… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

References

Publications referenced by this paper.
Showing 1-10 of 18 references