Effect of Tenofovir on Nucleotidases and Cytokines in HIV-1 Target Cells

  title={Effect of Tenofovir on Nucleotidases and Cytokines in HIV-1 Target Cells},
  author={Nabanita Biswas and Marta Rodr{\'i}guez-Garc{\'i}a and Sarah G. Crist and Zheng Shen and Jack E. Bodwell and John V. Fahey and Charles R Wira},
  booktitle={PloS one},
Tenofovir (TFV) has been widely used for pre-exposure prophylaxis of HIV-1 infection with mixed results. While the use of TFV in uninfected individuals for prevention of HIV-1 acquisition is actively being investigated, the possible consequences of TFV exposure for the HIV-target cells and the mucosal microenvironment are unknown. In the current study, we evaluated the effects of TFV treatment on blood-derived CD4⁺ T cells, monocyte-derived macrophages and dendritic cells (DC). Purified HIV… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS
5 Citations
44 References
Similar Papers


Publications referenced by this paper.
Showing 1-10 of 44 references

Similar Papers

Loading similar papers…