Effect of Tenapanor on Interdialytic Weight Gain in Patients on Hemodialysis.

@article{Block2016EffectOT,
  title={Effect of Tenapanor on Interdialytic Weight Gain in Patients on Hemodialysis.},
  author={Geoffrey A. Block and David P Rosenbaum and Maria Leonsson-Zachrisson and Bergur V. Stef{\'a}nsson and Tina Ryd{\'e}n-Bergsten and Peter J Greasley and Susanne Johansson and Mikael Knutsson and Bj{\"o}rn Carlsson},
  journal={Clinical journal of the American Society of Nephrology : CJASN},
  year={2016},
  volume={11 9},
  pages={
          1597-605
        }
}
BACKGROUND AND OBJECTIVES Interdialytic weight gain in patients on hemodialysis is associated with adverse cardiovascular outcomes and increased mortality. The degree of interdialytic weight gain is influenced by sodium intake. We evaluated the effects of tenapanor (AZD1722 and RDX5791), a minimally systemically available inhibitor of the sodium/hydrogen exchanger isoform 3, on interdialytic weight gain in patients with CKD stage 5D treated with hemodialysis. DESIGN, SETTING, PARTICIPANTS… Expand

Paper Mentions

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  • 2018
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The present narrative review aims to evaluate the efficacy of various strategies proposed to limit interdialytic weight gain such as the reduction of dietary salt intake, behavioral interventions aimed at improving the adherence to fluid restriction, the improvement of xerostomia, and the use of lower dialysate sodium concentration. Expand
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The data suggest the effect of tenapanor on sodium absorption is most pronounced when administered before meals, whereas the effect on phosphate is similar whether administered before or after meals, which may support different timings ofTenapanor administration with respect to food for sodium‐ and phosphate‐related indications. Expand
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The physiology of thirst in patients on chronic hemodialysis is described, as well as the prevalence, its measures, the associated variables, the consequences, and the strategies for its reduction. Expand
Pharmacodynamics, Safety, and Tolerability of the NHE3 Inhibitor Tenapanor: Two Trials in Healthy Volunteers
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Tenapanor was well tolerated and resulted in reduced intestinal sodium absorption and softer stool consistency versus placebo, and potential use of tenapanor in patients who could benefit from modification of gastrointestinal sodium balance is supported. Expand
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