Effect of Temperature and Light on the Stability of Latanoprost and its Clinical Relevance

  title={Effect of Temperature and Light on the Stability of Latanoprost and its Clinical Relevance},
  author={Pamela Valerie Morgan and Stefan Proniuk and James Blanchard and Robert J. Noecker},
  journal={Journal of Glaucoma},
PurposeTo examine the effect of controlled heat and ultraviolet exposures on the stability of latanoprost (Xalatan, Pharmacia & Upjohn, Kalamazoo, MI) using high-performance liquid chromatography to derive practical recommendations for patients regarding its use and storage. MethodsUsing serial dilution of a latanoprost stock solution, varying concentrations were prepared to obtain a standard curve. The accuracy and precision of the high-performance liquid chromatography assay conditions were… 
Thermal stability of bimatoprost, latanoprost, and travoprost under simulated daily use.
Under the conditions of thermal stress tested in this study, bimatoprost remained stable for all conditions tested, likely a result of evaporation.
Efficacy of latanoprost when stored at room temperature.
The results suggest that latanoprost stored at 30 degrees C for 4 weeks after opening the bottle remains as effective and safe as lataniprost stored under cold conditions.
Investigation of surfactants suitable for stabilizing of latanoprost.
There was no influence on the stability of latanoprost when adding benzalkonium chloride, as a preservative, to a formulation involving these surfactants involving the polyoxyethylene chain and the straight-chain alkyl group.
A versatile LC method for the simultaneous quantification of latanoprost , timolol and benzalkonium chloride and related substances in the presence of their degradation products in ophthalmic solution
A challenging and multipurpose stability-indicating HPLC method is developed and validated for the quantification of latanoprost, timolol, benzalkonium chloride (BKC) and related substances in the
High‐Performance Liquid Chromatography Determination of Latanoprost in Pharmaceutical Formulations using UV Detection
Abstract A simple, fast, and accurate high‐performance liquid chromatography (HPLC) method was developed to determine latanoprost in pharmaceutical formulations. The drug was chromatographed on a C18
Simple, fast, and sensitive isocratic high-performance liquid chromatography method for the quantification of latanoprost
Summary A simple, sensitive, fast, and accurate isocratic high-performance liquid chromatography (HPLC) method with UV detection (205 nm) has been developed and validated for the quantification of
The stabilization mechanism of latanoprost.
It was shown that the latanoprost is stabilized by the interaction with complex micelles, which was effective for the inhibition of both adsorption and degradation.
Comparative study of the stability of bimatoprost 0.03% and latanoprost 0.005%: A patient-use study
This study showed that bimatoprost maintained ≥100% concentration throughout the study period while latanoprost did not, and it was found that unstable drugs may require refrigeration to preserve their active ingredient level and they are more susceptible to degradation based on patient mishandling.
Stability of Latanoprost in Generic Formulations Using Controlled Degradation and Patient Usage Simulation Studies
Packaging with gas tight containers may be one of the important factors for latanoprost stability, along with its storage at low temperature during patient usage, according to this study.
Latanoprost is water insoluble and is unstable against heat stress due to hydrolysis of the isopropyl ester in the latanoprost molecule. Therefore, the storage condition of latanoprost ophthalmic


The pharmacokinetics of a new antiglaucoma drug, latanoprost, in the rabbit.
Most of the radioactivity found in the aqueous humor, anterior eye tissues, and plasma corresponded to the pharmacologically active acid of latanoprost, and the recovery of radioactivity was complete.
Effects of PhXA41, A New Prostaglandin F2α Analog, on Aqueous Humor Dynamics in Human Eyes
PhXA41, a new phenyl-substituted analog of a prostaglandin F 2α (PGF 2α ) prodrug, is an effective ocular hypotensive agent in patients with glaucoma as well as other parameters of aqueous humor dynamics.
Prostaglandin F2 alpha-isopropylester eye drops: effect on intraocular pressure in open-angle glaucoma.
In 30 patients with previously untreated open-angle glaucoma an intraocular pressure (IOP) curve was taken before and during treatment with PGF2 alpha-isopropylester eye drops in one eye and the effect was maintained and even slightly increased during the week.
Maintained reduction of intraocular pressure by prostaglandin F2 alpha-1-isopropyl ester applied in multiple doses in ocular hypertensive and glaucoma patients.
The findings show that PGF2 alpha-IE is a potent ocular hypotensive agent and a promising drug for glaucoma therapy.
Derivatives of 17-phenyl-18,19,20-trinorprostaglandin F2 alpha isopropyl ester: potential antiglaucoma agents.
The 15R and 15S epimers of a series of phenyl substituted analogs of 17-phenyl-18,19,20-trinorprostaglandin F2 alpha isopropyl ester [(15S-3] have been synthesized and the activity profile of (15S)-3 may be changed by the introduction of substituents in the benzene ring.
UV‐B increases (1979–1992) from decreases in total ozone
Increases in ultraviolet fluxes (300 nm to 340 nm) reaching the ground between 1979 and 1992 are estimated using measured stratospheric ozone amounts and reflectivity data from Nimbus-7/TOMS (Total
Biostatistics: A Foundation for Analysis in the Health Sciences
Introduction to Biostatistics Descriptive Statistics Some Basic Probability Concepts Probability Distributions Some Important Sampling Distributions Estimation Hypothesis Testing Analysis of Variance
Third communication: tissue distribution after topical administration on the eye studied by whole body autoradiography
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The effect of latanoprost (PhXA41) on the intraocular concentration: a randomized, double masked comparison of 50 g/ml vs 15 g/ml with timolol 0.5% as control
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